Post by Lyme Challenged on Feb 24, 2023 21:58:42 GMT -5
Thomas Grier
More to come:
What Lyme disease Support Leaders Need to Know
For those Lyme disease advocates who have been around since 1990, this is repetition, but it bears repeating because the medical community in 32 years has not corrected their errors.
This is an annotated outline of what is wrong with the CDC and IDSA position on Lyme disease diagnosis, testing, and treatment.Print this out, date it, and put it on your refrigerator to see if a anything changes in another 30+ years? Thomas Grier
The Gold Standard
By Tom Grier
In microbiology we were always taught that the gold-standard for determining infection was pathology. This includes culturing organisms, staining for bacteria in tissues, and visual confirmation with various microscopes. Somewhere in time since of Borrelia burgdorferi was first isolated in 1982 by both microscopy and culturing Bb from both ticks and patient-rashes, the “Gold-Standard” switched from pathology to serology-testing. Why?
Mostly there are three reasons:
1) Cheaper: Serology tests are far cheaper and easier than culturing
2) Greed: The same administrators at the CDC that held the patents on the early Lyme disease ELISA tests also proselytized how good/accurate they were, and mandated the use of the CDC-only ELISA tests by every state. They used tax=payer monies to create serology tests that they profit from by putting the patents in the names of at least six CDC officers.
3) Assumptions: What was true for most bacterial infections was not true of spirochetes
A) There are many Species of Lyme, not just Borrelia burgdorferi: It was assumed that only Borrelia burgdorferi species caused Lyme Borreliosis. As of today, at least 17 species of Borrelia worldwide cause Lyme disease. The problem is that each Lyme serology blood-test must be programed for each individual species of Borrelia and this creates a nightmare for patents and royalties.
B) IgM/IgG antibody response: In most infections IgM antibodies mean early infection, this is not true of deep tissue infections Like Lyme disease. But to ignore the IgM positives the CDC and IDSA called IgM results unreliable. This is not true: As deep tissue Lyme infections reemerge; the IgM response becomes active. There are no memory-T cells for IgM so positive IgM is active infection.
C) Lyme is often a neurologic Brain-Infection: We were told without investigation that Borrelia doesn’t get into the human brain. We were told serology tests could detect Borrelia inside the brain, but we were also told that Borrelia doesn’t enter the human brain. (Dr. Alan Barbour in his book and radio interviews.) Yet in 1945 we knew a sister bacterium Borrelia turicatae gets into animal brains and was incurable even with heroic doses of penicillin. (Schutzhardt 1945, J. Science)
D) Avoiding being discredited: The early Lyme disease experts were wrong about many Lyme facts, and they knew pathology proves them wrong. This is why the CDC has not spent one research dollar on human brain pathology and relied on rigged animal studies and serology-testing to make their incorrect “facts” appear to be true.
The Lyme disease experts told us outright lies about Lyme disease knowing they were lies. One needs only look at early quotes in the NY Times by the “Lyme-experts” prior to 1998 when the truth slipped out, and compare them to their quotes after 1998.
Quotes:
William Harvey 1651
Physician to King James the 1st “I appeal to your own eyes as my witness and judge. The heart of animals is their foundation of life.I profess to learn and teach anatomy, not from books but from dissections, not from opinions of philosophers but from the fabric of nature” “Unless the bull’s-eye rash is the size of a basketball or bigger, it isn’t Lyme Disease” (Duluth Infectious Disease doctor and IDSA President) Duluth AM Radio Talk 2012 “All true Lyme patients get a rash, they either just don’t see it or they don’t have Lyme, and not having Lyme disease is the more likely of the two. “
There is no Lyme disease in St. Louis County St. Louis County Epidemiologist 1995 “All Lyme disease patients have a swollen knee.” Duluth Family Practice 1994 Quotes about Lyme disease from national Lyme disease experts and Infectious Disease doctors 10/04/2007 There is no evidence that "chronic Lyme disease" exists and if it does, the risks of prolonged “There is no evidence of transplacental transfer of Lyme disease from the mother to the fetus.”
Dr. Gary Wormser
Under Our Skin 2008 antibiotic treatment outweigh any benefits.” (review article Yale Medical Report) (Alan Steere, Gary Wormser) Yale Medicine Special Report May 15th 1996 by Marc Voortman Ticks must be attached for 48 hours or more
Do not treat any rash with antibiotics
Symptoms like Bell’s Palsy, or swollen knee require an ELISA
test before treating with antibiotics
If this test is negative don’t treat
Any lingering symptoms will take up to 3 months to dissipate
Do not treat with antibiotics again
Repeat ELISA test. If this test is positive do not treat, give a Western Blot and only treat if it is positive “There is no evidence of transplacental transfer of Lyme disease from the mother to the fetus.”
Dr. Gary Wormser
Under Our Skin 2008Borrelia burgdorferi, as well as other co-infections, can be transmitted from an infected mother to the fetus through the placenta during any stage of pregnancy.Steere et al., Ann Intern Med 1985; 103(1): 67-8
Dr. Raymond Dattwyler, at Stony Brook, said: “The typical Lyme disease patient has a rash but no other symptoms, takes an antibiotic and is cured.”
6/13/2001 New York Times
• Dr. Finkle - Wisconsin 1-800 Lyme Disease Help Line 1993 “If you have had two weeks of IV Rocephin for Lyme disease you don’t have Lyme disease anymore. It kills all the bacteria everywhere in the body! Think about it… it circulates through the whole body!”
• Caller: “So it kills all the bacteria in the GI tract in two weeks and Syphilis and acne too?” “The bacterium that causes Lyme disease likes the blood-stream. It rarely leaves the blood-stream, and even more rarely enters organs like the brain. It cannot easily penetrate cells. Because it stays in the blood it is easy to detect and easy to treat.” Dr. Alan Barbour – National Public Radio Call in show 2016 “The bacterium that causes Lyme disease likes the blood-stream. It rarely leaves the blood-stream, and even more rarely enters organs like the brain. It cannot easily penetrate cells. Because it stays in the blood it is easy to detect and easy to treat.” Dr. Alan Barbour – National Public Radio Call in show 2016 Alan Barbour (CDC) "These findings indicate that a function of the OspC family of proteins of Borrelia, may be to allow localization of infection in host organs, including the brain, during infection."
"Lyme disease bacteria remain in the skin for two or more days until spreading to the other parts of the body. Until the microorganisms spread, there is no need for an antibiotic that is distributed throughout the body” Alan Barbour, MD Lyme Disease, The Cause, The Cure, The Controversy, page 225 "Eventually, antibodies, perhaps aided by lymphocytes, attach to spirochetes in the blood and remove them from the circulation. However, by the time that occurs, some spirochetes have left the blood and entered distant organs. They are able to do this because they can attach themselves to the sides of blood vessels and then penetrate the cells that line veins and arteries. Once they reach the other side of the blood vessels, spirochetes can reside and move in the liquid between cells” Alan Barbour, MD, ibid., page 9 The B. burgdorferi organism may spend some of its life inside human cells.
After all, for these bacteria to leave the blood and go into tissues; they must pass through cells that line the blood vessels. . . . these intracellular spirochetes can escape the effects of the antibiotics that do not penetrate into cells. The live bacteria inside the host cells could reseed the rest of the body” Alan Barbour, ibid., pages 125-126 John Chunn MD (Pediatrician) Bend Oregon Pediatric specialist Chunn said: “Long-term antibiotic therapy is not needed to treat Lyme disease, because the bacteria are so easy to kill.” “This bacteria dies so easily you can’t believe it. It just rolls over and dies.” “If you get exposed and get treated,” said Dr. John Chunn, a Bend pediatrician and specialist in infectious diseases, you will be positive for 10 years!” Bend Bulletin, May 2009 – “A Disease in Debate” Nadelman Ostroff "Lyme is a yuppie disease that only rich suburbanites get."
Dr. Steven Ostroff, Associate Director in the Infectious Diseases Division of the Centers for Disease Control and Prevention during interview by Illinois legislators in June 1997 "The erythema migrans rash, which occurs within a mean of 7 to 10 days after a tick bite, is present in 90% or more of patients with objective evidence of Lyme disease "Nadelman, ibid., page 69
Lyme disease, although a problem, is not nearly as big a problem as most people think." The bigger epidemic," Dr. Sigal said, "is Lyme anxiety." And, he said, "even if you get the disease, it is easily treatable and it is curable."
Leonard H. Sigal, MD "We remain skeptical that antibiotic therapy helps” Allen C. Steere, et al. Annals of Internal Medicine 86 (1997): 685 "Lyme disease, although a problem, is not nearly as big a problem as most people think." The bigger epidemic," Dr. Sigal said, "is Lyme anxiety." And, he said, "even if you get the disease, it is easily treatable and it is curable." Leonard H. Sigal, MD Quoted by Gina Kolata in New York Times, June 13, 2001 “The symptoms [of Lyme disease] are slowly progressive, I think, with the spirochete still present. But syphilis is treatable with antibiotics, and so is Lyme disease . . . and central nervous system symptoms in Lyme disease, like CNS symptoms seen in syphilis, can occur after a long latent period” Allen C. Steere, MD, ibid Interlaboratory Comparison of Test Results for Detection of Lyme Disease by 516 Participants in the Wisconsin State Laboratory of Hygiene/College of American Pathologists Proficiency Testing Program
LORI L. BAKKEN, STEVEN M. CALLISTER, PHILIP J. WAND, AND RONALD F. SCHELL
In 1991 - 55% of 516 laboratories could not accurately identify serum samples from Lyme disease patients. containing antibody against Borrelia burgdorferi.
Borreila burgdorferi lato species
(Divided into 8 serotypes)
USA
B. burgdorferi
B. bissettii
B. spielmanii
B. lonestarrii
B. andersoni
B. americana
B. carolinesis
B. kurtenbachii
ASIA
B. japonica, B. miyamotoi (Russia)
B. turdi, B. sinica, B. tanukii
Dr. Raymond Dattwyler (1988 director of Lyme Disease Stony Brook) This disease can involve virtually every organ system of the body,'' Dr. Dattwyler said. ''It makes sense to look at this as a whole-body disease, rather than narrowly. In syphilis, which is a similar spirochetal illness in some ways, there is also an arthritis. If I concentrated on that aspect of syphilis, it would be ludicrous. You wouldn't see the forest for the trees, and I think it's the same thing with this disease.''
The choice of antibiotic and dosage given is extremely important, according to the investigators [Dattwyler], because there is evidence that the bacteria goes into the brain soon after infection and most antibiotics cannot cross the blood brain barrier. Normal doses of oral penicillin or tetracycline, the conventional antibiotics of choice for the treatment of early Lyme Disease, are not adequate to inhibit the bacteria, in the opinions of the researchers at Stony Brook.
New York Times, 6/12/1988
Arthritis Rheum. 1987 Apr;30,4:448-50. Failure of tetracycline therapy in early Lyme disease. Dattwyler RJ, Halperin JJ. We describe 5 patients with Lyme disease who developed significant late symptoms and complications despite receiving tetracycline early in the course of their illness. All 5 patients had been treated in rash stage with a course of tetracycline that met or exceeded current IDSA recommendations. The symptoms included: arthritis, cranial nerve palsy, peripheral neuropathy, chronic fatigue, and changes in mental function. Our findings suggest that the use of tetracycline at a dosage of 250 mg, 4 times a day for 10 days, as a treatment for early Lyme disease should be reconsidered.
Sep 15, 1987 Chicago Tribune
Lyme disease can produce severe nervous system disorders that look like brain tumors, Alzheimer’s disease, and multiple sclerosis, sometimes condemning patients to years of needless suffering because of misdiagnosis.
Dr John Halperin SUNY
We isolated Borrelia burgdorferi from the blood of seven patients with Lyme disease four months after treatment.
Gary Wormser, Robert Nadelman American Journal of Medicine, 1990 (88:21-26) IDSA Lyme Disease Guidelines
More to come:
What Lyme disease Support Leaders Need to Know
For those Lyme disease advocates who have been around since 1990, this is repetition, but it bears repeating because the medical community in 32 years has not corrected their errors.
This is an annotated outline of what is wrong with the CDC and IDSA position on Lyme disease diagnosis, testing, and treatment.Print this out, date it, and put it on your refrigerator to see if a anything changes in another 30+ years? Thomas Grier
The Gold Standard
By Tom Grier
In microbiology we were always taught that the gold-standard for determining infection was pathology. This includes culturing organisms, staining for bacteria in tissues, and visual confirmation with various microscopes. Somewhere in time since of Borrelia burgdorferi was first isolated in 1982 by both microscopy and culturing Bb from both ticks and patient-rashes, the “Gold-Standard” switched from pathology to serology-testing. Why?
Mostly there are three reasons:
1) Cheaper: Serology tests are far cheaper and easier than culturing
2) Greed: The same administrators at the CDC that held the patents on the early Lyme disease ELISA tests also proselytized how good/accurate they were, and mandated the use of the CDC-only ELISA tests by every state. They used tax=payer monies to create serology tests that they profit from by putting the patents in the names of at least six CDC officers.
3) Assumptions: What was true for most bacterial infections was not true of spirochetes
A) There are many Species of Lyme, not just Borrelia burgdorferi: It was assumed that only Borrelia burgdorferi species caused Lyme Borreliosis. As of today, at least 17 species of Borrelia worldwide cause Lyme disease. The problem is that each Lyme serology blood-test must be programed for each individual species of Borrelia and this creates a nightmare for patents and royalties.
B) IgM/IgG antibody response: In most infections IgM antibodies mean early infection, this is not true of deep tissue infections Like Lyme disease. But to ignore the IgM positives the CDC and IDSA called IgM results unreliable. This is not true: As deep tissue Lyme infections reemerge; the IgM response becomes active. There are no memory-T cells for IgM so positive IgM is active infection.
C) Lyme is often a neurologic Brain-Infection: We were told without investigation that Borrelia doesn’t get into the human brain. We were told serology tests could detect Borrelia inside the brain, but we were also told that Borrelia doesn’t enter the human brain. (Dr. Alan Barbour in his book and radio interviews.) Yet in 1945 we knew a sister bacterium Borrelia turicatae gets into animal brains and was incurable even with heroic doses of penicillin. (Schutzhardt 1945, J. Science)
D) Avoiding being discredited: The early Lyme disease experts were wrong about many Lyme facts, and they knew pathology proves them wrong. This is why the CDC has not spent one research dollar on human brain pathology and relied on rigged animal studies and serology-testing to make their incorrect “facts” appear to be true.
The Lyme disease experts told us outright lies about Lyme disease knowing they were lies. One needs only look at early quotes in the NY Times by the “Lyme-experts” prior to 1998 when the truth slipped out, and compare them to their quotes after 1998.
Quotes:
William Harvey 1651
Physician to King James the 1st “I appeal to your own eyes as my witness and judge. The heart of animals is their foundation of life.I profess to learn and teach anatomy, not from books but from dissections, not from opinions of philosophers but from the fabric of nature” “Unless the bull’s-eye rash is the size of a basketball or bigger, it isn’t Lyme Disease” (Duluth Infectious Disease doctor and IDSA President) Duluth AM Radio Talk 2012 “All true Lyme patients get a rash, they either just don’t see it or they don’t have Lyme, and not having Lyme disease is the more likely of the two. “
There is no Lyme disease in St. Louis County St. Louis County Epidemiologist 1995 “All Lyme disease patients have a swollen knee.” Duluth Family Practice 1994 Quotes about Lyme disease from national Lyme disease experts and Infectious Disease doctors 10/04/2007 There is no evidence that "chronic Lyme disease" exists and if it does, the risks of prolonged “There is no evidence of transplacental transfer of Lyme disease from the mother to the fetus.”
Dr. Gary Wormser
Under Our Skin 2008 antibiotic treatment outweigh any benefits.” (review article Yale Medical Report) (Alan Steere, Gary Wormser) Yale Medicine Special Report May 15th 1996 by Marc Voortman Ticks must be attached for 48 hours or more
Do not treat any rash with antibiotics
Symptoms like Bell’s Palsy, or swollen knee require an ELISA
test before treating with antibiotics
If this test is negative don’t treat
Any lingering symptoms will take up to 3 months to dissipate
Do not treat with antibiotics again
Repeat ELISA test. If this test is positive do not treat, give a Western Blot and only treat if it is positive “There is no evidence of transplacental transfer of Lyme disease from the mother to the fetus.”
Dr. Gary Wormser
Under Our Skin 2008Borrelia burgdorferi, as well as other co-infections, can be transmitted from an infected mother to the fetus through the placenta during any stage of pregnancy.Steere et al., Ann Intern Med 1985; 103(1): 67-8
Dr. Raymond Dattwyler, at Stony Brook, said: “The typical Lyme disease patient has a rash but no other symptoms, takes an antibiotic and is cured.”
6/13/2001 New York Times
• Dr. Finkle - Wisconsin 1-800 Lyme Disease Help Line 1993 “If you have had two weeks of IV Rocephin for Lyme disease you don’t have Lyme disease anymore. It kills all the bacteria everywhere in the body! Think about it… it circulates through the whole body!”
• Caller: “So it kills all the bacteria in the GI tract in two weeks and Syphilis and acne too?” “The bacterium that causes Lyme disease likes the blood-stream. It rarely leaves the blood-stream, and even more rarely enters organs like the brain. It cannot easily penetrate cells. Because it stays in the blood it is easy to detect and easy to treat.” Dr. Alan Barbour – National Public Radio Call in show 2016 “The bacterium that causes Lyme disease likes the blood-stream. It rarely leaves the blood-stream, and even more rarely enters organs like the brain. It cannot easily penetrate cells. Because it stays in the blood it is easy to detect and easy to treat.” Dr. Alan Barbour – National Public Radio Call in show 2016 Alan Barbour (CDC) "These findings indicate that a function of the OspC family of proteins of Borrelia, may be to allow localization of infection in host organs, including the brain, during infection."
"Lyme disease bacteria remain in the skin for two or more days until spreading to the other parts of the body. Until the microorganisms spread, there is no need for an antibiotic that is distributed throughout the body” Alan Barbour, MD Lyme Disease, The Cause, The Cure, The Controversy, page 225 "Eventually, antibodies, perhaps aided by lymphocytes, attach to spirochetes in the blood and remove them from the circulation. However, by the time that occurs, some spirochetes have left the blood and entered distant organs. They are able to do this because they can attach themselves to the sides of blood vessels and then penetrate the cells that line veins and arteries. Once they reach the other side of the blood vessels, spirochetes can reside and move in the liquid between cells” Alan Barbour, MD, ibid., page 9 The B. burgdorferi organism may spend some of its life inside human cells.
After all, for these bacteria to leave the blood and go into tissues; they must pass through cells that line the blood vessels. . . . these intracellular spirochetes can escape the effects of the antibiotics that do not penetrate into cells. The live bacteria inside the host cells could reseed the rest of the body” Alan Barbour, ibid., pages 125-126 John Chunn MD (Pediatrician) Bend Oregon Pediatric specialist Chunn said: “Long-term antibiotic therapy is not needed to treat Lyme disease, because the bacteria are so easy to kill.” “This bacteria dies so easily you can’t believe it. It just rolls over and dies.” “If you get exposed and get treated,” said Dr. John Chunn, a Bend pediatrician and specialist in infectious diseases, you will be positive for 10 years!” Bend Bulletin, May 2009 – “A Disease in Debate” Nadelman Ostroff "Lyme is a yuppie disease that only rich suburbanites get."
Dr. Steven Ostroff, Associate Director in the Infectious Diseases Division of the Centers for Disease Control and Prevention during interview by Illinois legislators in June 1997 "The erythema migrans rash, which occurs within a mean of 7 to 10 days after a tick bite, is present in 90% or more of patients with objective evidence of Lyme disease "Nadelman, ibid., page 69
Lyme disease, although a problem, is not nearly as big a problem as most people think." The bigger epidemic," Dr. Sigal said, "is Lyme anxiety." And, he said, "even if you get the disease, it is easily treatable and it is curable."
Leonard H. Sigal, MD "We remain skeptical that antibiotic therapy helps” Allen C. Steere, et al. Annals of Internal Medicine 86 (1997): 685 "Lyme disease, although a problem, is not nearly as big a problem as most people think." The bigger epidemic," Dr. Sigal said, "is Lyme anxiety." And, he said, "even if you get the disease, it is easily treatable and it is curable." Leonard H. Sigal, MD Quoted by Gina Kolata in New York Times, June 13, 2001 “The symptoms [of Lyme disease] are slowly progressive, I think, with the spirochete still present. But syphilis is treatable with antibiotics, and so is Lyme disease . . . and central nervous system symptoms in Lyme disease, like CNS symptoms seen in syphilis, can occur after a long latent period” Allen C. Steere, MD, ibid Interlaboratory Comparison of Test Results for Detection of Lyme Disease by 516 Participants in the Wisconsin State Laboratory of Hygiene/College of American Pathologists Proficiency Testing Program
LORI L. BAKKEN, STEVEN M. CALLISTER, PHILIP J. WAND, AND RONALD F. SCHELL
In 1991 - 55% of 516 laboratories could not accurately identify serum samples from Lyme disease patients. containing antibody against Borrelia burgdorferi.
Borreila burgdorferi lato species
(Divided into 8 serotypes)
USA
B. burgdorferi
B. bissettii
B. spielmanii
B. lonestarrii
B. andersoni
B. americana
B. carolinesis
B. kurtenbachii
ASIA
B. japonica, B. miyamotoi (Russia)
B. turdi, B. sinica, B. tanukii
Dr. Raymond Dattwyler (1988 director of Lyme Disease Stony Brook) This disease can involve virtually every organ system of the body,'' Dr. Dattwyler said. ''It makes sense to look at this as a whole-body disease, rather than narrowly. In syphilis, which is a similar spirochetal illness in some ways, there is also an arthritis. If I concentrated on that aspect of syphilis, it would be ludicrous. You wouldn't see the forest for the trees, and I think it's the same thing with this disease.''
The choice of antibiotic and dosage given is extremely important, according to the investigators [Dattwyler], because there is evidence that the bacteria goes into the brain soon after infection and most antibiotics cannot cross the blood brain barrier. Normal doses of oral penicillin or tetracycline, the conventional antibiotics of choice for the treatment of early Lyme Disease, are not adequate to inhibit the bacteria, in the opinions of the researchers at Stony Brook.
New York Times, 6/12/1988
Arthritis Rheum. 1987 Apr;30,4:448-50. Failure of tetracycline therapy in early Lyme disease. Dattwyler RJ, Halperin JJ. We describe 5 patients with Lyme disease who developed significant late symptoms and complications despite receiving tetracycline early in the course of their illness. All 5 patients had been treated in rash stage with a course of tetracycline that met or exceeded current IDSA recommendations. The symptoms included: arthritis, cranial nerve palsy, peripheral neuropathy, chronic fatigue, and changes in mental function. Our findings suggest that the use of tetracycline at a dosage of 250 mg, 4 times a day for 10 days, as a treatment for early Lyme disease should be reconsidered.
Sep 15, 1987 Chicago Tribune
Lyme disease can produce severe nervous system disorders that look like brain tumors, Alzheimer’s disease, and multiple sclerosis, sometimes condemning patients to years of needless suffering because of misdiagnosis.
Dr John Halperin SUNY
We isolated Borrelia burgdorferi from the blood of seven patients with Lyme disease four months after treatment.
Gary Wormser, Robert Nadelman American Journal of Medicine, 1990 (88:21-26) IDSA Lyme Disease Guidelines