Post by Lyme Challenged on Aug 4, 2017 3:29:49 GMT -5
Thomas Grier
The 10th and Final Excerpt from the Seven Provocative findings of Dr Alan MacDonald RetiredPathologist:
The Seventh Provocative Discovery by Alan MacDonald:
In 1992 Amy Jones, Dr. Paul Duray’s pathology assistant, found Borrelia burgdorferi in the breast milk of infected mothers, and she found B. burgdorferi in the semen of infected men.
While sexual transmission of Lyme disease has been speculated it is a difficult thing to prove cause and effect. Borreliosis is not like syphilis where shortly after sex a noticeable uniquely identifiable rash (chancre) forms. In Lyme it is suspected that it may take months or years to manifest symptoms, but no one has proven sexual transmission in humans.
Work by the legendary veterinarian Dr. Elizabeth Burgess DVM PhD showed in 1990 that dogs infected with Lyme disease were transmitting and infecting female dogs through sexual transmission. Still the proof in humans is lacking. The presence of the bacteria is not proof, but indicates a strong likelihood.
What Alan found was the presence of both B. burgdorferi and B. mayonii in the testicle of a logger from Twig, Minnesota. What is provocative is that this man had been treated almost continuously on antibiotics for the last seven years of his life. Yet he still had live Borrelia in both his brain and testicle. He also had B. miyamotoi in his brain.
The case for sexual transmission is stronger than ever. Borrelia survives in the testicle despite aggressive and prolonged antibiotics.
What this means to the Medical Community?
Lyme disease and some Relapsing Fevers are probably sexually transmitted. Aggressive antibiotics may not be enough to eradicate Borrelia from the testicle. So short of abstinence the best prevention of sexual transmission is the use of a condom between couples. Also treat all Borrelia infections early and aggressively to prevent the establishment of Borrelia in immune privileged sites like the testicles and sequestered sites where antibiotics have less effect.
Above: Large white arrow points to a nematode egg (oval structure) – Spirochetes dwell inside of the egg (green, thread-like structures). 1000 x magnification- Oil immersion. DNA probe for Inner cell membrane ORF of Borrelia burgdorferi ( sl) FAMILY of borrelia sub-species Bbo 0740 Molecular Beacon Dna Probe- FISH method study of autopsy testicle from a Minnesota Man.
Below: Borrelia mayonii species – visualized with DNA probe tagged with Nile Blue fluorochromes – 400x magnification – White arrow
Cautionary note:
Nematode infestations of the CNS require very careful treatment and monitoring by an experienced physician. Patients should not attempt to self-treat. Some anthelminthics can cause severe inflammatory reactions which might require concomitant steroid treatment in order to avoid a fatal encephalitis.
FISH probes developed by Dr. MacDonald embody hope for the future
To date Dr. Alan MacDonald has developed specific probes for three Borrelia species: Borrelia burgdorferi, B. miyamotoi, and B. mayonii. These have been capable of detecting a range of strains including European borrelia.
The probes are “Molecular Beacon” DNA probes which have an excellent rate of accuracy. They will not give off their fluorescent signal unless every single nucleotide (component unit) of the target DNA sequence matches perfectly. So when we use these probes we can be very sure that we are detecting Borrelia and not something else.
These DNA probes could open the door to accurate diagnosis in the future. As we have seen, they are already unlocking the secrets of Borrelial involvement in major neurodegenerative diseases.
But more research needs to be done before these findings will be accepted by the wider medical community. And to do this, we need your help. All of the work here at the Foundation is done on a non-profit basis. We do not receive any government or industry funding, but rely on donations from patients and other interested individuals. Please support our work by giving generously, and by encouraging organisations with which you are affiliated to do the same. Together we can bring to light the full spectrum of Borrelia and Nematode worm involvement in neurological disease, and help bring about cure.
Please click here to donate to the Dr. Paul Duray Research Fellowship Foundation.
durayresearch.wordpress.com/donate/
Further Reading:
Borrelia and Nematode Worms in Neurodegenerative Disease:
Alzheimer’s Disease and Lewy Body Dementia
durayresearch.wordpress.com/…/alzheimers-disease-a…/
spirodementia.wordpress.com/parasitic-nematode-wor…/
spirodementia.files.wordpress.com/…/thursposter-alz…
durayresearch.wordpress.com/…/lewy-body-dementia-a…/
Multiple Sclerosis
durayresearch.wordpress.com/o…/multiple-sclerosis-2/
Brain Tumors (Glioblastoma multiforme)
durayresearch.wordpress.com/…/glioblastoma-multifo…/
DNA Probes prove failure of antibody tests to detect Borrelia infections
durayresearch.wordpress.com/…/lyme-serology-dna-pr…/
Videos
Dr Alan MacDonald explains his findings of Borrelia and Nematodes in MS, Lewy Body Disease, and Brain Tumor, London AONM conference May 2016
vimeo.com/166685590
Presentation by Dr. MacDonald in which he traces the history of his Alzheimer’s research up till 2014. Also discusses the evidence of mother-to-child transmission, and the failure of current antibody tests in diagnosis. June 2014
www.youtube.com/channel/UCQAFF2MF1YHuPHCF7oF2JHQ
The 10th and Final Excerpt from the Seven Provocative findings of Dr Alan MacDonald RetiredPathologist:
The Seventh Provocative Discovery by Alan MacDonald:
In 1992 Amy Jones, Dr. Paul Duray’s pathology assistant, found Borrelia burgdorferi in the breast milk of infected mothers, and she found B. burgdorferi in the semen of infected men.
While sexual transmission of Lyme disease has been speculated it is a difficult thing to prove cause and effect. Borreliosis is not like syphilis where shortly after sex a noticeable uniquely identifiable rash (chancre) forms. In Lyme it is suspected that it may take months or years to manifest symptoms, but no one has proven sexual transmission in humans.
Work by the legendary veterinarian Dr. Elizabeth Burgess DVM PhD showed in 1990 that dogs infected with Lyme disease were transmitting and infecting female dogs through sexual transmission. Still the proof in humans is lacking. The presence of the bacteria is not proof, but indicates a strong likelihood.
What Alan found was the presence of both B. burgdorferi and B. mayonii in the testicle of a logger from Twig, Minnesota. What is provocative is that this man had been treated almost continuously on antibiotics for the last seven years of his life. Yet he still had live Borrelia in both his brain and testicle. He also had B. miyamotoi in his brain.
The case for sexual transmission is stronger than ever. Borrelia survives in the testicle despite aggressive and prolonged antibiotics.
What this means to the Medical Community?
Lyme disease and some Relapsing Fevers are probably sexually transmitted. Aggressive antibiotics may not be enough to eradicate Borrelia from the testicle. So short of abstinence the best prevention of sexual transmission is the use of a condom between couples. Also treat all Borrelia infections early and aggressively to prevent the establishment of Borrelia in immune privileged sites like the testicles and sequestered sites where antibiotics have less effect.
Above: Large white arrow points to a nematode egg (oval structure) – Spirochetes dwell inside of the egg (green, thread-like structures). 1000 x magnification- Oil immersion. DNA probe for Inner cell membrane ORF of Borrelia burgdorferi ( sl) FAMILY of borrelia sub-species Bbo 0740 Molecular Beacon Dna Probe- FISH method study of autopsy testicle from a Minnesota Man.
Below: Borrelia mayonii species – visualized with DNA probe tagged with Nile Blue fluorochromes – 400x magnification – White arrow
Cautionary note:
Nematode infestations of the CNS require very careful treatment and monitoring by an experienced physician. Patients should not attempt to self-treat. Some anthelminthics can cause severe inflammatory reactions which might require concomitant steroid treatment in order to avoid a fatal encephalitis.
FISH probes developed by Dr. MacDonald embody hope for the future
To date Dr. Alan MacDonald has developed specific probes for three Borrelia species: Borrelia burgdorferi, B. miyamotoi, and B. mayonii. These have been capable of detecting a range of strains including European borrelia.
The probes are “Molecular Beacon” DNA probes which have an excellent rate of accuracy. They will not give off their fluorescent signal unless every single nucleotide (component unit) of the target DNA sequence matches perfectly. So when we use these probes we can be very sure that we are detecting Borrelia and not something else.
These DNA probes could open the door to accurate diagnosis in the future. As we have seen, they are already unlocking the secrets of Borrelial involvement in major neurodegenerative diseases.
But more research needs to be done before these findings will be accepted by the wider medical community. And to do this, we need your help. All of the work here at the Foundation is done on a non-profit basis. We do not receive any government or industry funding, but rely on donations from patients and other interested individuals. Please support our work by giving generously, and by encouraging organisations with which you are affiliated to do the same. Together we can bring to light the full spectrum of Borrelia and Nematode worm involvement in neurological disease, and help bring about cure.
Please click here to donate to the Dr. Paul Duray Research Fellowship Foundation.
durayresearch.wordpress.com/donate/
Further Reading:
Borrelia and Nematode Worms in Neurodegenerative Disease:
Alzheimer’s Disease and Lewy Body Dementia
durayresearch.wordpress.com/…/alzheimers-disease-a…/
spirodementia.wordpress.com/parasitic-nematode-wor…/
spirodementia.files.wordpress.com/…/thursposter-alz…
durayresearch.wordpress.com/…/lewy-body-dementia-a…/
Multiple Sclerosis
durayresearch.wordpress.com/o…/multiple-sclerosis-2/
Brain Tumors (Glioblastoma multiforme)
durayresearch.wordpress.com/…/glioblastoma-multifo…/
DNA Probes prove failure of antibody tests to detect Borrelia infections
durayresearch.wordpress.com/…/lyme-serology-dna-pr…/
Videos
Dr Alan MacDonald explains his findings of Borrelia and Nematodes in MS, Lewy Body Disease, and Brain Tumor, London AONM conference May 2016
vimeo.com/166685590
Presentation by Dr. MacDonald in which he traces the history of his Alzheimer’s research up till 2014. Also discusses the evidence of mother-to-child transmission, and the failure of current antibody tests in diagnosis. June 2014
www.youtube.com/channel/UCQAFF2MF1YHuPHCF7oF2JHQ